Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis.

Abstract

BACKGROUND/AIMS Autoantibodies with specificity for the E2 component of the pyruvate dehydrogenase complex (PDC-E2) are commonly present in primary biliary cirrhosis. The aim of this study was to generate and characterise human anti-PDC-E2 monoclonal antibodies and analyse immunoglobulin gene usage and mutation for clues to pathogenesis. METHODS… (More)

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Cite this paper

@article{Thomson1998ImmunogeneticAO, title={Immunogenetic analysis of a panel of monoclonal IgG and IgM anti-PDC-E2/X antibodies derived from patients with primary biliary cirrhosis.}, author={Robert K Thomson and Zoe H Davis and Jane M. Palmer and Michael J P Arthur and Samuel Yeaman and C J Chapman and Myfanwy B. Spellerberg and Fiona Stevenson}, journal={Journal of hepatology}, year={1998}, volume={28 4}, pages={582-94} }