Immunofluorescent monoclonal antibody detection of breast cancer in bone marrow: sensitivity in a model system.

@article{Osborne1989ImmunofluorescentMA,
  title={Immunofluorescent monoclonal antibody detection of breast cancer in bone marrow: sensitivity in a model system.},
  author={Michael P. Osborne and Shirin Asina and Gilbert Y. Wong and L. John Old and Richard J. Cote},
  journal={Cancer research},
  year={1989},
  volume={49 9},
  pages={2510-3}
}
We have previously shown that occult micrometastases can be detected in the bone marrow of breast cancer patients using a panel of epithelial specific monoclonal antibodies in an indirect immunofluorescent assay. The sensitivity of this assay has been examined using cells from an established human breast cancer cell line (MCF-7) mixed with normal bone marrow at various dilutions from 400 cancer cells/10(6) marrow cells (400:10(6] to 10:10(6). MCF-7 cells were detected at the lowest… CONTINUE READING
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Fluorescent monoclonal antibody detection of occult microme tastases in the bone marrow

  • P Osborne.M., R. J. Cote, T. B. Hakes, Kinne, J D.W..Old.L., P. P. Rosen
  • Cancer Invest.,
  • 1988
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