Immunofluorescence localization of the Na-Ca exchanger in heart cells.

  title={Immunofluorescence localization of the Na-Ca exchanger in heart cells.},
  author={R S Kieval and Robert J Bloch and George E. Lindenmayer and A Ambesi and W. Jonathan Lederer},
  journal={The American journal of physiology},
  volume={263 2 Pt 1},
We investigated the localization of the Na-Ca exchanger in fixed, isolated heart cells from rat and guinea pig using immunocytochemical methods with epifluorescence and confocal microscopy. We found that the Na-Ca exchanger is distributed throughout all membranes in contact with the extracellular space, including the sarcolemma, the transverse tubules (T-tubules), and the intercalated disks. Microscopic nonuniformities in the fluorescent labeling appear to reflect varying views of the membranes… CONTINUE READING

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