Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ.

@article{Nilsson1998ImmunofluorescenceCO,
  title={Immunofluorescence characterization of key extracellular matrix proteins in murine bone marrow in situ.},
  author={Susan K Nilsson and Michelle E Debatis and Mark S. Dooner and Joseph A. Madri and Peter J Quesenberry and Pamela S Becker},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1998},
  volume={46 3},
  pages={371-7}
}
The mechanism of hemopoietic stem cell homing to the bone marrow involves molecular interactions that mediate the recognition and interaction of these cells with the marrow microenvironment, including the extracellular matrix. On selective binding, this environment, in combination with soluble cytokines, regulates stem cell proliferation and differentiation. Using immunofluorescence labeling, we analyzed the location of the prominent extracellular matrix proteins fibronectin, collagen Types I… CONTINUE READING

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