Immunoelectron microscopic localization of platelet factor 4 and fibrinogen in the granules of human platelets.

@article{Pham1983ImmunoelectronML,
  title={Immunoelectron microscopic localization of platelet factor 4 and fibrinogen in the granules of human platelets.},
  author={T. Pham and K. Kaplan and V. P. Butler},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1983},
  volume={31},
  pages={905 - 910}
}
  • T. Pham, K. Kaplan, V. P. Butler
  • Published 1983
  • Biology, Medicine
  • The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society
To determine the storage site of platelet fibrinogen and of platelet factor 4 (PF4) in human platelets by immunoelectron microscopic techniques, washed human platelets were briefly exposed to Karnovsky's fixative and embedded in water-soluble Durcupan. Thin sections of platelets were exposed to Fab fragments of rabbit anti-human fibrinogen or of goat anti-human PF4, followed by a peroxidase conjugate of Fab fragments of antibodies to rabbit immunoglobulin (Ig) G or to goat IgG. The technique… Expand
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