Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma Membrane

@inproceedings{Hammonds2010ImmunoelectronME,
  title={Immunoelectron Microscopic Evidence for Tetherin/BST2 as the Physical Bridge between HIV-1 Virions and the Plasma Membrane},
  author={Jason E Hammonds and Jaang-Jiun Wang and Hong Yi and Paul Spearman},
  booktitle={PLoS pathogens},
  year={2010}
}
Tetherin/BST2 was identified in 2008 as the cellular factor responsible for restricting HIV-1 replication at a very late stage in the lifecycle. Tetherin acts to retain virion particles on the plasma membrane after budding has been completed. Infected cells that express large amounts of tetherin display large strings of HIV virions that remain attached to… CONTINUE READING