Immunoediting of cancers may lead to epithelial to mesenchymal transition.

  title={Immunoediting of cancers may lead to epithelial to mesenchymal transition.},
  author={Keith L. Knutson and Hailing Lu and Brad Stone and Jennifer M Reiman and Marshall D. Behrens and Christine M. Prosperi and Ekram A. Gad and Arianna Smorlesi and Mary Lenora Disis},
  journal={Journal of immunology},
  volume={177 3},
Tumors evade both natural and pharmacologically induced (e.g., vaccines) immunity by a variety of mechanisms, including induction of tolerance and immunoediting. Immunoediting results in reshaping the immunogenicity of the tumor, which can be accompanied by loss of Ag expression and MHC molecules. In this study, we evaluated immunoediting in the neu-transgenic mouse model of breast cancer. A tumor cell line that retained expression of rat neu was generated from a spontaneous tumor of the neu… CONTINUE READING


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