Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.

@article{Schmidt2011ImmunodominanceOH,
  title={Immunodominance of HLA-A2-restricted hepatitis C virus-specific CD8+ T cell responses is linked to naive-precursor frequency.},
  author={Julia Schmidt and Christoph Neumann-Haefelin and Tayibe Altay and Emma Gostick and David A. Price and Volker Lohmann and H. E. Blum and Robert Thimme},
  journal={Journal of virology},
  year={2011},
  volume={85 10},
  pages={5232-6}
}
The impact of naïve-precursor frequency on human virus-specific CD8(+) T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a >10-fold difference in naïve-precursor frequencies across three HLA-A2-restricted hepatitis C virus (HCV)-specific epitopes. Importantly, the NS3(1406) epitope with the highest naïve-precursor frequency in healthy donors was also the most… CONTINUE READING

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