Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity.

  title={Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity.},
  author={Nicole A Mifsud and Anthony W. Purcell and Wenhao Chen and Rhonda Holdsworth and Brian D. Tait and James McCluskey},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  volume={8 1},
Allogeneic solid organ transplantation often occurs across multiple donor-recipient HLA mismatches with consequent risk of allograft rejection. However, there is growing evidence that not all HLA mismatches are equivalent in their stimulation of allogeneic T cells making it important to determine which of these might be more significant as predictors of allograft rejection. To this end, we used defined antigen-presenting cell (APC) transfectants expressing single MHC-I allotypes as target cells… CONTINUE READING

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