Immunodiscrimination of colorectal neoplasia using MUC1 antibodies: discrepant findings in tissue versus stool.

@article{Limburg2000ImmunodiscriminationOC,
  title={Immunodiscrimination of colorectal neoplasia using MUC1 antibodies: discrepant findings in tissue versus stool.},
  author={Paul J. Limburg and David A. Ahlquist and Jorge A. Gilbert and Jonathan J. Harrington and George G. Klee and Patrick C. Roche},
  journal={Digestive diseases and sciences},
  year={2000},
  volume={45 3},
  pages={494-9}
}
Colorectal tumor-associated antigens are attractive targets for novel stool-screening assays. MUC1, a glycoprotein antigen, is aberrantly expressed in transformed colorectal mucosa and represents a candidate fecal biomarker. In this study, tissue staining and stool testing were performed to further clarify the discriminant potential of MUC1 in markedly different biologic media. One anti-MUC1 monoclonal antibody (MA5) was used for immunohistochemistry and two commercially available MUC1 assay… CONTINUE READING