Immunodetection of cells with a CD44+/CD24- phenotype in canine mammary neoplasms

  title={Immunodetection of cells with a CD44+/CD24- phenotype in canine mammary neoplasms},
  author={Ge{\'o}rgia Mod{\'e} Magalh{\~a}es and Erika Maria Terra and Rosemeri de Oliveira Vasconcelos and M{\'a}rcio de Barros Bandarra and Pamela Rodrigues Reina Moreira and Mayara Caroline Rosolem and Ant{\^o}nio Carlos Alessi},
  booktitle={BMC veterinary research},
BACKGROUND Cancer stem cells (CSCs) are able to self-renew and to form metastases. Using flow cytometry, CSCs were detected in canine mammary tumors as cells CD44(+) and CD24(-). The aim of this study was to detect these CSCs by immunohistochemistry and correlate their frequency with canine mammary neoplasm grade and histopathological type.130 mammary neoplasm samples were selected from tissue blocks at the Department of Pathology at UNESP and classified according to (BJVP 4:153-180, 2011… CONTINUE READING
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