Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke.

@article{Saino2010ImmunodeficiencyRN,
  title={Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke.},
  author={Orie Saino and A. Hisanori Taguchi and Takayuki Nakagomi and Akiko Nakano-Doi and Shin-ichiro Kashiwamura and Nobutaka Doe and Nami Nakagomi and Toshihiro Soma and Hiroo Yoshikawa and David M. Stern and Haruki Okamura and Tomohiro Matsuyama},
  journal={Journal of neuroscience research},
  year={2010},
  volume={88 11},
  pages={2385-97}
}
Acute inflammation in the poststroke period exacerbates neuronal damage and stimulates reparative mechanisms, including neurogenesis. However, only a small fraction of neural stem/progenitor cells survives. In this report, by using a highly reproducible model of cortical infarction in SCID mice, we examined the effects of immunodeficiency on reduction of brain injury, survival of neural stem/progenitor cells, and functional recovery. Subsequently, the contribution of T lymphocytes to… CONTINUE READING
41 Citations
36 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 41 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 36 references

Similar Papers

Loading similar papers…