Immunodeficiency lentiviral infections in natural and non-natural hosts.

@article{Brenchley2011ImmunodeficiencyLI,
  title={Immunodeficiency lentiviral infections in natural and non-natural hosts.},
  author={Jason M. Brenchley and Mirko Paiardini},
  journal={Blood},
  year={2011},
  volume={118 4},
  pages={
          847-54
        }
}
The host immune system is profoundly affected during the acute phase of progressive immunodeficiency lentiviral infections. Studies of these alterations have been quite restricted in humans because of the limited availability of samples from acutely HIV-infected persons. Therefore, numerous studies have turned attention to nonhuman primate models. Specifically, SIV-infected rhesus macaques (RMs) have been informative for understanding the pathogenesis of HIV infection in humans. Indeed… CONTINUE READING
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