Immunodeficiency in children with acute lymphoblastic leukemia after completion of modern aggressive chemotherapeutic regimens.

@article{Brodtman2005ImmunodeficiencyIC,
  title={Immunodeficiency in children with acute lymphoblastic leukemia after completion of modern aggressive chemotherapeutic regimens.},
  author={Daniel H Brodtman and David W. Rosenthal and Arlene Redner and Philip Lanzkowsky and Vincent R Bonagura},
  journal={The Journal of pediatrics},
  year={2005},
  volume={146 5},
  pages={654-61}
}
OBJECTIVE To determine the prevalence, duration, and a potential cause of humoral defect(s) in children with acute lymphoblastic leukemia (ALL) at least 1 year after completion of chemotherapy. STUDY DESIGN Antibody titers for mumps, rubeola, rubella, tetanus and diphtheria toxoid, poliovirus serotypes 1, 2,and 3, Haemophilus influenzae type b, varicella, and hepatitis B were obtained from 100 children with ALL. Children with non-protective titers to these microbial antigens were re… CONTINUE READING

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