Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders.

@article{Pecci2002ImmunocytochemistryFT,
  title={Immunocytochemistry for the heavy chain of the non-muscle myosin IIA as a diagnostic tool for MYH9-related disorders.},
  author={Alessandro Pecci and Patrizia Noris and Rosangela Invernizzi and Anna Savoia and Marco Seri and Gian Marco Ghiggeri and Saverio Sartore and Simone Gangarossa and Nicola Bizzaro and Carlo Luigi Balduini},
  journal={British journal of haematology},
  year={2002},
  volume={117 1},
  pages={164-7}
}
May-Hegglin anomaly (MHA), Sebastian syndrome (SBS) and Fechtner syndrome (FTNS) are autosomal-dominant macrothrombocytopenias with Döhle-like leucocyte inclusions. These diseases are due to mutations of the MHY9 gene, encoding the heavy chain of non-muscle myosin IIA (NMMHC-A). We investigated the NMMHC-A localization in blood cells from eight MHA, SBS or FTNS patients with known MYH9 mutations. All the patients showed an altered localization of NMMHC-A in granulocytes and platelets… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 27 extracted citations

Expression of non-muscle type myosin heavy polypeptide 9 (MYH9) in mammalian cells.

European journal of histochemistry : EJH • 2003
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…