Immunocytochemical localization of the quinolinic acid synthesizing enzyme, 3-hydroxyanthranilic acid oxygenase, in the rat substantia nigra.

@article{Roberts1994ImmunocytochemicalLO,
  title={Immunocytochemical localization of the quinolinic acid synthesizing enzyme, 3-hydroxyanthranilic acid oxygenase, in the rat substantia nigra.},
  author={Rosalinda C. Roberts and Kevin E McCarthy and F Q Du and Etsuo Okuno and Robert M. Schwarcz},
  journal={Brain research},
  year={1994},
  volume={650 2},
  pages={229-38}
}
Quinolinic acid, an endogenous excitatory amino acid receptor agonist, may play a role in several brain diseases. In the present study, the immunocytochemical localization of 3-hydroxyanthranilic acid oxygenase (3HAO), the enzyme responsible for the synthesis of quinolinic acid, was examined in the adult rat substantia nigra at the light and electron microscopic levels. 3HAO-immunoreactivity was detected exclusively in astrocytes. Labeling was present in cell bodies and in fine glial processes… CONTINUE READING