Immunocytochemical localization of S-100b protein in degenerating and regenerating rat sciatic nerves.

@article{Spreca1989ImmunocytochemicalLO,
  title={Immunocytochemical localization of S-100b protein in degenerating and regenerating rat sciatic nerves.},
  author={Antonio Spreca and Maria Grazia Rambotti and Mario Rende and Carla Saccardi and Maria Cristina Aisa and Ileana Giambanco and Rosario Donato},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1989},
  volume={37 4},
  pages={441-6}
}
We studied the cellular and subcellular distribution of S-100b protein in normal, crushed, and transected rat sciatic nerves by an immunocytochemical procedure. In uninjured nerves, S-100b protein was restricted to the cytoplasm and membranes of Schwann cells, with no reaction product present in the nucleus or in axons. Similar images were seen from the first to the thirtieth day after the crush in activated Schwann cells during the degeneration period, i.e., up to the seventh post-lesion day… CONTINUE READING