Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.

@article{Kleinz2005ImmunocytochemicalLO,
  title={Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells.},
  author={Matthias J Kleinz and Jeremy N. Skepper and Anthony P. Davenport},
  journal={Regulatory peptides},
  year={2005},
  volume={126 3},
  pages={233-40}
}
The novel G protein-coupled receptor APJ, recently paired with the proposed cognate peptide ligand apelin, mediates potent vasodilator and positive inotropic actions in rats. Radioligand binding showed apelin receptors in rat and human heart and human large conduit vessels. The specific cell types expressing the receptor, however, have not been determined. Apelin, the cognate receptor ligand, is present in endothelial cells. However, the exact pathway of endothelial apelin synthesis and… CONTINUE READING

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