Immunocytochemical identification of nuclear structures containing snRNPs in isolated rat liver cells.

@article{Puvion1984ImmunocytochemicalIO,
  title={Immunocytochemical identification of nuclear structures containing snRNPs in isolated rat liver cells.},
  author={Edmond Puvion and Annie Viron and Christophe Assens and Elizabeth H. Leduc and P. Jeanteur},
  journal={Journal of ultrastructure research},
  year={1984},
  volume={87 2},
  pages={180-9}
}
Small nuclear ribonucleoproteins (snRNPs) containing U1, U2, U4, U5, and U6 small nuclear RNAs were detected by ultrastructural immunocytochemistry in the nuclei of isolated rat hepatocytes using Fab fragments of anti-Sm and anti-RNP autoantibodies. Their localization was carried out in normal cells and in cells treated with two drugs, the adenosine analog DRB and CdCl2, which alter the number and distribution of nuclear RNP components. It was found that more precise determination of the… CONTINUE READING

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