Immunocytochemical detection of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in rodent tissue sections.
@article{Terheggen1987ImmunocytochemicalDO, title={Immunocytochemical detection of interaction products of cis-diamminedichloroplatinum(II) and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) with DNA in rodent tissue sections.}, author={P. Terheggen and B. Floot and E. Scherer and A. Begg and A. M. Fichtinger-Schepman and L. den Engelse}, journal={Cancer research}, year={1987}, volume={47 24 Pt 1}, pages={ 6719-25 } }
Calf thymus DNA was modified in vitro by cis-diamminedichloroplatinum(II) (cisDDP), complexed with methylated bovine serum albumin and used to immunize rabbits. The anti-cisDDP-DNA antiserum obtained was applied in a double peroxidase-antiperoxidase staining procedure to localize cisDDP-DNA and cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II) (CBDCA)-DNA interaction products in cryostat tissue sections of mice and rats. Rats received cisDDP (0-10 mg/kg) and were killed after 24 h. Mice… CONTINUE READING
Figures, Tables, and Topics from this paper
68 Citations
Correlation between cell killing by cis-diamminedichloroplatinum(II) in six mammalian cell lines and binding of a cis-diamminedichloroplatinum(II)-DNA antiserum.
- Medicine, Biology
- Cancer research
- 1990
- 57
- PDF
Cellular distribution of cis-diamminedichloroplatinum(II)-DNA binding in rat dorsal root spinal ganglia: effect of the neuroprotecting peptide ORG.2766.
- Biology, Medicine
- Toxicology and applied pharmacology
- 1989
- 36
Polyclonal antibodies elicited against trans-diamminedichloroplatinum(II)-modified DNA and their application in nonradioactive hybridization experiments.
- Chemistry, Medicine
- European journal of biochemistry
- 1991
- 10
Antibodies against cisplatin-modified DNA and cisplatin-modified (di) nucleotides
- Chemistry, Medicine
- Cancer Chemotherapy and Pharmacology
- 2004
- 17
Conversion of DNA adducts of antitumour cis-diamminedichloroplatinum(II). Immunochemical analysis.
- Chemistry, Medicine
- European journal of pharmacology
- 1992
- 8
The formation and persistence of carboplatin-DNA adducts in rats
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
- 1996
- 24
Sensitive detection of DNA modifications induced by cisplatin and carboplatin in vitro and in vivo using a monoclonal antibody.
- Medicine
- Cancer research
- 1991
- 69
- PDF
Postlabeling detection of DNA adducts of antitumor alkylating agents
- Chemistry, Medicine
- Cancer Chemotherapy and Pharmacology
- 1996
- 1
Immunocytochemical analysis of cisplatin-induced platinum-DNA adducts with double-fluorescence video microscopy.
- Biology, Medicine
- British Journal of Cancer
- 1997
- 17
- PDF
References
SHOWING 1-10 OF 35 REFERENCES
Antibodies elicited against cis-diamminedichloroplatinum(II)-modified DNA are specific for cis-diamminedichloroplatinum(II)-DNA adducts formed in vivo and in vitro.
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1982
- 99
- PDF
Polyclonal antibodies to quantitate cis-diamminedichloroplatinum(II)--DNA adducts in cancer patients and animal models.
- Biology, Medicine
- Environmental health perspectives
- 1985
- 55
Adducts of the antitumor drug cis-diamminedichloroplatinum(II) with DNA: formation, identification, and quantitation.
- Chemistry, Medicine
- Biochemistry
- 1985
- 884
Immunochemical quantitation of adducts induced in DNA by cis-diamminedichloroplatinum (II) and analysis of adduct-related DNA-unwinding.
- Chemistry, Medicine
- Chemico-biological interactions
- 1985
- 79
Mechanism of cytotoxicity of anticancer platinum drugs: evidence that cis-diamminedichloroplatinum(II) and cis-diammine-(1,1-cyclobutanedicarboxylato)platinum(II) differ only in the kinetics of their interaction with DNA.
- Medicine
- Cancer research
- 1986
- 497
- PDF
Quantitation of cis-diamminedichloroplatinum II (cisplatin)-DNA-intrastrand adducts in testicular and ovarian cancer patients receiving cisplatin chemotherapy.
- Biology, Medicine
- The Journal of clinical investigation
- 1986
- 145
- PDF
DNA cross-linking as an indicator of sensitivity and resistance of mouse L1210 leukemia to cis-diamminedichloroplatinum(II) and L-phenylalanine mustard.
- Biology, Medicine
- Cancer research
- 1981
- 230
- PDF
Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II).
- Biology, Medicine
- Cancer research
- 1985
- 116
- PDF
Measurement of O6-ethyldeoxyguanosine and N-(deoxyguanosin-8-yl)-N-acetyl-2-aminofluorene in DNA by high-sensitive enzyme immunoassays.
- Chemistry, Medicine
- Carcinogenesis
- 1982
- 41
Resistance against cis-dichlorodiammineplatinum in cultured cells with a high content of metallothionein.
- Chemistry, Medicine
- Toxicology and applied pharmacology
- 1981
- 180