Immunocytochemical demonstration of hormonally regulable casein in tumors produced by a rat mammary stem cell line.

@article{Rudland1983ImmunocytochemicalDO,
  title={Immunocytochemical demonstration of hormonally regulable casein in tumors produced by a rat mammary stem cell line.},
  author={Philip Spencer Rudland and Christine M. Hughes and Anthony C. Davies and Michael J. Warburton},
  journal={Cancer research},
  year={1983},
  volume={43 7},
  pages={3305-9}
}
The rat mammary epithelial stem cell line, Rat Mammary 25, and the dimethyl sulfoxide-resistant variant derived from it, Rama 259, when injected separately into female, virgin, athymic nude mice formed tumors which grew at approximately the same rate. When the mice were mated, the growth rate of the Rama 259 tumors increased 2.5-fold during late pregnancy and lactation, while that of the Rama 25 tumors was unaffected. The tumors in all cases consisted of glandular-like structures and blocks of… CONTINUE READING