Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis

@article{Murayama1989ImmunocytochemicalAU,
  title={Immunocytochemical and ultrastructural study of Lewy body-like hyaline inclusions in familial amyotrophic lateral sclerosis},
  author={Shigeo Murayama and Y. Ookawa and Hideo Mori and Imaharu Nakano and Yasuo Ihara and Shigeki Kuzuhara and Masanori Tomonaga},
  journal={Acta Neuropathologica},
  year={1989},
  volume={78},
  pages={143-152}
}
Lewy body-like hyaline inclusion (LI) in the neuronal soma and swollen cord-like processes is a characteristic feature in the anterior horn cells and neurons in thoracic nucleus (Clarke) of familial amyotrophic lateral sclerosis (ALS) with posterior column involvement. We have studied the LI in the case of two sisters with this disorders. Microscopically the LI consists of an eosinophilic “core” surrounded by a basophilic “halo”. Ultrastructurally the core consists of granule-associated… CONTINUE READING

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