Immunocytochemical analysis of the glucocorticoid receptor alpha isoform (GRalpha) using GRalpha-specific antibody.

@article{Oakley1999ImmunocytochemicalAO,
  title={Immunocytochemical analysis of the glucocorticoid receptor alpha isoform (GRalpha) using GRalpha-specific antibody.},
  author={Robert H. Oakley and J. Christopher Webster and Christine M Jewell and Madhabananda Sar and John Anthony Cidlowski},
  journal={Steroids},
  year={1999},
  volume={64 10},
  pages={742-51}
}
The alpha isoform of the glucocorticoid receptor (GRalpha) binds glucocorticoids and functions as a ligand-dependent transcription factor. Although GRalpha is expressed in almost all tissues and cells, its subcellular distribution is controversial. Many studies have reported that GRalpha translocates from the cytoplasm to the nucleus in a hormone-dependent manner whereas others have concluded that GRalpha is constitutively located in the nucleus. These conflicting data may result from the use… CONTINUE READING

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