Immunocytochemical analysis of human synovial lining cells: phenotypic relation to other marrow derived cells.

Abstract

The antigenic phenotype of human synovial lining cells in normal and hyperplastic synovium intima was determined with a panel of monoclonal antibodies directed against a large number of well defined myeloid (macrophage/granulocyte associated) antigens. Synovial lining cells express numerous macrophage associated antigens, including CD11b (CR3), CD13, CD14, CD16 (FcRIII), CD18, CD32 (FcRII), CD45 (leucocyte common antigen), CD54 (ICAM-1), CD64 (FcRI), CD68, and CD71 (transferrin receptor). Few synovial lining cells expressed CD11a (LFA-1) and CD11c (p150,95). Subintimal macrophages expressed all the macrophage associated antigens which were present on synovial lining cells and, in addition, expressed CD15a, CD25 (interleukin-2 receptor), CD34, and CD35 (C3b receptor), none of which was present on synovial lining cells. Synovial lining cell expression of a wide range of macrophage antigens argues in favour of their marrow origin and membership of the mononuclear phagocyte system.

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@article{Athanasou1991ImmunocytochemicalAO, title={Immunocytochemical analysis of human synovial lining cells: phenotypic relation to other marrow derived cells.}, author={Nicholas Anthony Athanasou and Jacqueline Quinn}, journal={Annals of the rheumatic diseases}, year={1991}, volume={50 5}, pages={311-5} }