Immunoconjugates containing novel maytansinoids: promising anticancer drugs.

  title={Immunoconjugates containing novel maytansinoids: promising anticancer drugs.},
  author={Ravi V. J. Chari and Bridget A Martell and Janet L. Gross and Sandra B. Cook and Syed Qarib Abbas Shah and Walter A. Bl{\"a}ttler and Sil{\^a}n McKenzie and Victor S. Goldmacher},
  journal={Cancer research},
  volume={52 1},
The potential of immunoconjugates of cytotoxic drugs for the treatment of cancer has not yet been realized owing to the difficulty of delivering therapeutic concentrations of these drugs to the target cells. In an effort to overcome this problem we have synthesized maytansinoids that have 100- to 1000-fold higher cytotoxic potency than clinically used anticancer drugs. These maytansinoids are linked to antibodies via disulfide bonds, which ensures the release of fully active drug inside the… CONTINUE READING
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product p 185

  • C. F. Scott, V. S. Goldmacher, J. M. Lambert, J. V. Jackson, G. D. McIntyre
  • 1989

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