Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.

@article{Pericle1997ImmunocompromisedTM,
  title={Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.},
  author={Federica Pericle and Robert A. Kirken and Vincenzo Bronte and Giuseppe Sconocchia and Luis Dasilva and David M. Segal},
  journal={Journal of immunology},
  year={1997},
  volume={159 6},
  pages={2580-5}
}
Impaired immune responses are frequently observed in tumor-bearing hosts during progression of tumor growth, but the molecular basis of these functional defects remains unclear. To investigate tumor-induced immunosuppression, we first established that lymphocytes from mice bearing s.c. mammary adenocarcinoma (TS/A) tumors were severely impaired in their ability to generate cellular and humoral Ag-specific responses. Lymphocytes from these mice were then screened for abnormalities in the… CONTINUE READING

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