Immunocompetent 3D Model of Human Upper Airway for Disease Modeling and In Vitro Drug Evaluation

@inproceedings{Harrington2014Immunocompetent3M,
  title={Immunocompetent 3D Model of Human Upper Airway for
Disease Modeling and In Vitro Drug Evaluation},
  author={H. Michael Harrington and Paul Cato and Fabi{\'a}n Salazar and Malcolm Wilkinson and Alan Knox and John W Haycock and Felicity R. A. J. Rose and Jon W. Aylott and Amir M. Ghaemmaghami},
  booktitle={Molecular pharmaceutics},
  year={2014}
}
The development of more complex in vitro models for the assessment of novel drugs and chemicals is needed because of the limited biological relevance of animal models to humans as well as ethical considerations. Although some human-cell-based assays exist, they are usually 2D, consist of single cell type, and have limited cellular and functional representation of the native tissue. In this study, we have used biomimetic porous electrospun scaffolds to develop an immunocompetent 3D model of the… CONTINUE READING
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