Immunochemotherapy of human colon carcinoma xenografts in nude mice using combinations of idarubicin-monoclonal antibody conjugates.

Abstract

Tumour cell heterogeneity is probably a principal cause of treatment failure and represents a formidable barrier for effective antibody-targeted chemotherapy. Idarubicin (Ida), a more potent and less cardiotoxic analogue of daunomycin, has been demonstrated to specifically target and eradicate homogeneous, cloned, murine tumour cell populations in vitro and… (More)

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@article{Smyth1993ImmunochemotherapyOH, title={Immunochemotherapy of human colon carcinoma xenografts in nude mice using combinations of idarubicin-monoclonal antibody conjugates.}, author={M. Smyth and Harris Foster and Sharon Andrew and Jeanette Teh and Kenia G. Krauer and Ian McKenzie and Gianni Pietersz}, journal={Immunology and cell biology}, year={1993}, volume={71 ( Pt 3)}, pages={167-79} }