Immunochemical detection of oxidatively damaged DNA

  title={Immunochemical detection of oxidatively damaged DNA},
  author={P. Rossner and R. Sram},
  journal={Free Radical Research},
  pages={492 - 522}
  • P. Rossner, R. Sram
  • Published 2012
  • Medicine, Chemistry
  • Free Radical Research
  • Abstract Oxidatively damaged DNA is implicated in various diseases, including neurodegenerative disorders, cancer, diabetes, cardiovascular and inflammatory diseases as well as aging. Several methods have been developed to detect oxidatively damaged DNA. They include chromatographic techniques, the Comet assay, 32P-postlabelling and immunochemical methods that use antibodies to detect oxidized lesions. In this review, we discuss the detection of 8-oxo-7,8-dihydro-29-deoxyguanosine (8-oxodG… CONTINUE READING
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