Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder.

@article{Stanley1996ImmunochemicalDO,
  title={Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder.},
  author={Lesley A. Stanley and E Coroneos and Ray L. Cuff and David Hickman and Andrew Martin Robert Ward and Edith Sim},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={1996},
  volume={44 9},
  pages={1059-67}
}
The N-acetyltransferase (NAT) phenotype is an important determinant of individual susceptibility to occupational bladder cancer. N-Acetyltransferases arc known to metabolize aromatic amine bladder carcinogens, but the functional significance of NAT expression in the target organ is unclear. To resolve this issue, polygonal antisera against purified recombinant enzymes and C-terminal peptides of human NAT Type 1 (NAT1) and Type 2 (NAT2) were generated. Western blot analysis of exfoliated cells… CONTINUE READING

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