Immunochemical detection of advanced glycosylation end products in vivo.

  title={Immunochemical detection of advanced glycosylation end products in vivo.},
  author={Zenji Makita and Helen Vlassara and Anthony Cerami and Richard Bucala},
  journal={The Journal of biological chemistry},
  volume={267 8},
Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking properties. These compounds, called advanced glycosylation end products (AGEs), have been implicated in the structural and functional alterations of proteins that occur during aging and long-term diabetes. Although several AGEs have been identified on the basis of de novo synthesis and tissue isolation procedures, the measurement of AGE compounds in vivo has… CONTINUE READING
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