Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.

@article{Ware1998ImmunochemicalDA,
  title={Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: possible role in allergic reactions.},
  author={J. Anthony Ware and Mary Louise M Graf and Brian M. Martin and Lisa Lustberg and Lance R. Pohl},
  journal={Chemical research in toxicology},
  year={1998},
  volume={11 3},
  pages={164-71}
}
Idiosyncratic adverse drug reactions are unpredictable, target multiple organ systems, and often become life-threatening events. Although the causes of idiosyncratic adverse drug reactions are not known in most cases, evidence suggests that they may be mediated through immunological mechanisms. It is generally thought that for a drug to lead to an immune response, it must first become covalently bound to a carrier protein. Since most drugs are unreactive, it is usually a reactive metabolite… CONTINUE READING