Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin

@article{Cocchia1981ImmunochemicalAI,
  title={Immunochemical and immunocytochemical localization of S-100 antigen in normal human skin},
  author={Domenico Cocchia and Fabrizio Michetti and Rosario Donato},
  journal={Nature},
  year={1981},
  volume={294},
  pages={85-87}
}
The S-100 antigen1 is generally considered to be unique to the nervous system, where it is found primarily in the cytoplasm and nucleus of glial cells, both in soluble and bound form2,3. It belongs to the family of acidic Ca2+-binding proteins4. In phylogenesis, S-100 conserves a close immunological relationship between different species, and during ontogenesis the pattern of its accumulation parallels the functional maturation of the nervous system2,3, although its biological role remains to… CONTINUE READING