Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse.

@article{Raunio1988ImmunochemicalAC,
  title={Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse.},
  author={Hannu Raunio and T Syngelm{\"a} and Markku J Pasanen and Risto Juvonen and Paavo Honkakoski and Matti V. Kairaluoma and E O Sotaniemi and Michael A. Lang and Olavi Pelkonen},
  journal={Biochemical pharmacology},
  year={1988},
  volume={37 20},
  pages={
          3889-95
        }
}
The cytochrome P-450-mediated coumarin 7-hydroxylase (COH) was studied in microsomal preparations from Wistar rat, DBA/2N mouse, and human liver. Human liver contained the highest constitutive COH activity of up to about 500 pmol/mg microsomal protein/min. The rat liver contained low levels of COH (about 3-5 pmol/mg protein/min) which could be demonstrated only with high substrate concentrations. Rabbit polyclonal antibody generated against P-450Coh (a P-450 isozyme purified from pyrazole… CONTINUE READING
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