Immunochemical and biomolecular studies of circulating immune complexes isolated from patients with acute and chronic hepatitis C virus infection.

@article{Sansonno1996ImmunochemicalAB,
  title={Immunochemical and biomolecular studies of circulating immune complexes isolated from patients with acute and chronic hepatitis C virus infection.},
  author={Domenico E. Sansonno and A R Iacobelli and V Cornacchiulo and Gianfranco Lauletta and M A Distasi and Pietro Gatti and Franco Dammacco},
  journal={European journal of clinical investigation},
  year={1996},
  volume={26 6},
  pages={465-75}
}
Circulating immune complexes (ICs) were isolated by affinity chromatography and sucrose density gradient fractionation during acute and chronic hepatitis C virus (HCV) infection. Immunochemical and biomolecular studies showed that they basically consist of the virus component, IgG with specific anti-HCV activity and IgM bearing 17.109 epitope (IgM 17.109), an antigenic determinant common to rheumatoid factors (RFs) with WA cross-idiotype (XId). An antigen-specific IC assay was used to… CONTINUE READING
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