Immunoblot Analyses of the Relative Contributions of Cysteine and Aspartic Proteases to Neurofilament Breakdown Products Following Experimental Brain Injury in Rats

@article{Posmantur2004ImmunoblotAO,
  title={Immunoblot Analyses of the Relative Contributions of Cysteine and Aspartic Proteases to Neurofilament Breakdown Products Following Experimental Brain Injury in Rats},
  author={R. Posmantur and X. Zhao and A. Kampfl and G. Clifton and R. Hayes},
  journal={Neurochemical Research},
  year={2004},
  volume={23},
  pages={1265-1276}
}
  • R. Posmantur, X. Zhao, +2 authors R. Hayes
  • Published 2004
  • Medicine, Biology
  • Neurochemical Research
  • Analyses using either one or two-dimensional gel electrophoresis were performed to identify the contribution of several proteases to lower molecular weight (MW) neurofilament 68 (NF68) break down products (BDPs) detected in cortical homogenates following unilateral cortical impact injury in rats. One dimensional immunoblot of BDPs obtained from in vitro cleavage of enriched neurofilaments (NF) by purified μ-calpain, m-calpain, cathepsin, B, cathepsin D, and CPP32 (caspase-3) were compared to in… CONTINUE READING
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