Immunobiology of human mucin 1 in a preclinical ovarian tumor model

  title={Immunobiology of human mucin 1 in a preclinical ovarian tumor model},
  author={Raluca Budiu and Esther L. Elishaev and Joan Brozick and M Lee and Robert Edwards and Pawel Kalinski and Anda M. Vlad},
Epithelial ovarian cancer is an aggressive malignancy, with a low 5-year median survival. Continued improvement on the development of more effective therapies depends in part on the availability of adequate preclinical models for in vivo testing of treatment efficacy. Mucin 1 (MUC1) glycoprotein is a tumor-associated antigen overexpressed in ovarian cancer cells, making it a potential target for immune therapy. To create a preclinical mouse model for MUC1-positive ovarian tumors, we generated… CONTINUE READING
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