Immunobiology of brain tumors.

  title={Immunobiology of brain tumors.},
  author={Yutaka Sawamura and Nicolas de Tribolet},
  journal={Advances and technical standards in neurosurgery},
In summary, many actual interactions between tumors in the CNS and the immune system have been demonstrated. The normal brain does not possess a lymphatic system and is partially hidden from the systemic immune system by the BBB, furthermore brain cells do not express MHC antigens which are necessary for the initiation of an immune response. In pathological conditions however, immunocompetent cells may find their way through transformed endothelial cells. Microglia and astrocytes may function… CONTINUE READING