Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement

@article{Jansen2007ImmunobiologicalDI,
  title={Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement},
  author={Mieke W. J. C. Jansen and Lilia Corral and V. H. J. van der Velden and Renate E Panzer-Gr{\"u}mayer and Martin Schrappe and Andr{\'e} Schrauder and Rolf Marschalek and Claus Meyer and M. J. L. den Boer and Wim C. J. Hop and Maria Grazia Valsecchi and Giuseppe Basso and Andrea Biondi and Rob Pieters and J J M van Dongen},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={633-641}
}
The aim of this study was to identify immunobiological subgroups in 133 infant acute lymphoblastic leukemia (ALL) cases as assessed by their immunophenotype, immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangement pattern, and the presence of mixed lineage leukemia (MLL) rearrangements. About 70% of cases showed the pro-B-ALL immunophenotype, whereas the remaining cases were common ALL and pre-B-ALL. MLL translocations were found in 79% of infants, involving MLL-AF4 (41%), MLL-ENL (18… CONTINUE READING