Immunobiological Effects of Glucosamine In Vitro

@article{Forchhammer2003ImmunobiologicalEO,
  title={Immunobiological Effects of Glucosamine In Vitro},
  author={Lykke Forchhammer and Mette Thorn and Ozcan Met and Monika Gad and Morten Sloth Weidner and Mogens Helweg Claesson},
  journal={Scandinavian Journal of Immunology},
  year={2003},
  volume={58}
}
Glucosamine (GlcN) and N‐acetyl‐d‐glucosamine (GlcNAc) were assayed in vitro for their effects on proliferation, cytotoxicity and cytokine secretion in primary and secondary mixed lymphocyte cultures (MLCs). In addition, we studied the effect of GlcN and GlcNAc on the proliferation of purified CD4+ T cells exposed to immobilized anti‐CD3 antibody. The present data show that GlcN, but not GlcNAc, inhibits CD4+ T‐cell proliferation, the generation of alloreactive cytotoxic T lymphocytes (CTLs… Expand
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