Immunoassay for the detection and quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV).

@article{Mcdougal1985ImmunoassayFT,
  title={Immunoassay for the detection and quantitation of infectious human retrovirus, lymphadenopathy-associated virus (LAV).},
  author={J. Steven Mcdougal and S P Cort and Michael S. Kennedy and C. D. Cabridilla and P M Feorino and Donald P. Francis and David William Hicks and Vaniambadi S. Kalyanaraman and Luc{\'i}a San Mart{\'i}n},
  journal={Journal of immunological methods},
  year={1985},
  volume={76 1},
  pages={
          171-83
        }
}
Detection of replicating human retroviruses has relied upon rather cumbersome reverse transcriptase, immunofluorescence, or electron microscopic assays. We describe a new sandwich enzyme-linked immunoassay (ELISA) for detecting the human retrovirus, lymphadenopathy-associated virus (LAV), in supernates of LAV-infected human lymphocyte cultures. This LAV capture immunoassay compares favorably with the reverse transcriptase assay, despite the fact that it is performed on 20-fold less supernate… CONTINUE READING

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