Immunoadsorption in severe C4d-positive acute kidney allograft rejection: a randomized controlled trial.

@article{Bhmig2007ImmunoadsorptionIS,
  title={Immunoadsorption in severe C4d-positive acute kidney allograft rejection: a randomized controlled trial.},
  author={Georg A B{\"o}hmig and Markus Wahrmann and Heinz M Regele and Markus Exner and Bernhard Robl and Kurt Derfler and T. H. Soliman and Peter Bauer and Michael J Muellner and Wilfred Druml},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2007},
  volume={7 1},
  pages={117-21}
}
Antibody-mediated rejection (AMR) frequently causes refractory graft dysfunction. This randomized controlled trial was designed to evaluate whether immunoadsorption (IA) is effective in the treatment of severe C4d-positive AMR. Ten out of 756 kidney allograft recipients were included. Patients were randomly assigned to IA with protein A (N = 5) or no such treatment (N = 5) with the option of IA rescue after 3 weeks. Enrolled recipients were subjected to tacrolimus conversion and, if indicated… CONTINUE READING

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