Immunoadjuvant prednisolone therapy for HIV-associated tuberculosis: a phase 2 clinical trial in Uganda.

@article{MayanjaKizza2005ImmunoadjuvantPT,
  title={Immunoadjuvant prednisolone therapy for HIV-associated tuberculosis: a phase 2 clinical trial in Uganda.},
  author={Harriet Mayanja-Kizza and Edward C. Jones-L{\'o}pez and Alphonse Okwera and Robert S Wallis and Jerrold J. Ellner and Roy D. Mugerwa and Christopher C Whalen},
  journal={The Journal of infectious diseases},
  year={2005},
  volume={191 6},
  pages={
          856-65
        }
}
Background. Human immunodeficiency virus (HIV)-infected patients with tuberculosis (TB) respond to effective antituberculous therapy, but their prognosis remains poor. Mounting evidence from clinical studies supports the concept of copathogenesis in which immune activation that is triggered by TB and mediated by cytokines stimulates viral replication and worsens HIV infection, especially when immune function is preserved.Methods. We performed a phase 2, randomized, double-blind, placebo… CONTINUE READING

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 47 CITATIONS

Use of corticosteroids in treating infectious diseases.

  • Archives of internal medicine
  • 2008
VIEW 4 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 47 REFERENCES

Association between tuberculosis and HIV disease progression in a high tuberculosis prevalence area.

  • The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease
  • 2001
VIEW 1 EXCERPT