Immunoactive two-dimensional self-assembly of monoclonal antibodies in aqueous solution revealed by atomic force microscopy.

Abstract

The conformational flexibility of antibodies in solution directly affects their immune function. Namely, the flexible hinge regions of immunoglobulin G (IgG) antibodies are essential in epitope-specific antigen recognition and biological effector function. The antibody structure, which is strongly related to its functions, has been partially revealed by… (More)
DOI: 10.1038/nmat3847

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@article{Ido2014ImmunoactiveTS, title={Immunoactive two-dimensional self-assembly of monoclonal antibodies in aqueous solution revealed by atomic force microscopy.}, author={Shinichiro Ido and Hirokazu Kimiya and Kei Kobayashi and Hiroaki Kominami and Kazumi Matsushige and Hirofumi Yamada}, journal={Nature materials}, year={2014}, volume={13 3}, pages={264-70} }