ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging

@article{Olafsen2012ImmunoPETUE,
  title={ImmunoPET using engineered antibody fragments: fluorine-18 labeled diabodies for same-day imaging},
  author={Tove Olafsen and Shannon J. Sirk and Sebastian Olma and Clifton K.-F. Shen and Anna M Wu},
  journal={Tumor Biology},
  year={2012},
  volume={33},
  pages={669-677}
}
Combining the specificity of tumor-targeting antibodies with the sensitivity and quantification offered by positron emission tomography (PET) provides tremendous opportunities for molecular characterization of tumors in vivo. Until recently, significant challenges have been faced when attempting to combine antibodies which show long biological half-lives and positron-emitting radionuclides with comparably short physical half-lives, in particular 18F (half-life, 109 min). A fast and simple… CONTINUE READING