ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment.

@article{Luo2017ImmunoPETAN,
  title={ImmunoPET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer with a Dual-Labeled Bispecific Antibody Fragment.},
  author={Haiming Luo and Christopher G. England and Shreya Goel and Stephen A. Graves and Fanrong Ai and Bai Fen Liu and Charles P. Theuer and Hing Choi Wong and Robert Jerry Nickles and Weibo Cai},
  journal={Molecular pharmaceutics},
  year={2017},
  volume={14 5},
  pages={
          1646-1655
        }
}
Dual-targeted imaging agents have shown improved targeting efficiencies in comparison to single-targeted entities. The purpose of this study was to quantitatively assess the tumor accumulation of a dual-labeled heterobifunctional imaging agent, targeting two overexpressed biomarkers in pancreatic cancer, using positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging modalities. A bispecific immunoconjugate (heterodimer) of CD105 and tissue factor (TF) Fab' antibody… CONTINUE READING
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