Immuno-spin trapping: detection of protein-centered radicals.

  title={Immuno-spin trapping: detection of protein-centered radicals.},
  author={D C Ramirez and Ronald Paul Mason},
  journal={Current protocols in toxicology},
  volume={Chapter 17},
  pages={Unit 17.7}
Protein-centered radicals are involved in biological oxidative damage induced by drugs, environmental hazards, and cellular reactive oxygen species. Presently, the technique most widely used to study protein-centered radicals is electron spin resonance (ESR; also known as electron paramagnetic resonance, EPR); used either directly or in combination with the spin-trapping technique. Protein-centered radicals may be trapped with the nitrone spin trap 5,5-dimethyl-1-pyrroline N-oxide (DMPO… CONTINUE READING


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