Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus.

@article{Moinuddin2015ImmunochemistryOH,
  title={Immuno-chemistry of hydroxyl radical modified GAD-65: A possible role in experimental and human diabetes mellitus.},
  author={Moinuddin Moinuddin and Nadeem Ahmad Ansari and Uzma Shahab and Safia Habeeb and Saheem Ahmad},
  journal={IUBMB life},
  year={2015},
  volume={67 10},
  pages={
          746-56
        }
}
The repertoire of known auto-antigens is limited to a very small proportion of all human proteins, and the reason why only some proteins become auto-antigens is unclear. The 65 kDa isoform of the enzyme glutamic acid decarboxylase (GAD-65) is a major auto-antigen in type I diabetes, and in various neurological diseases. Most patients with type I diabetes (70-80%) have auto-antibodies against GAD-65, which often appear years before clinical onset of the autoimmune diabetes. Thus, the aim of the… CONTINUE READING
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