Immuno-PCR: high sensitivity detection of proteins by nucleic acid amplification.

  title={Immuno-PCR: high sensitivity detection of proteins by nucleic acid amplification.},
  author={Christof M Niemeyer and Michael Adler and R. Wacker},
  journal={Trends in biotechnology},
  volume={23 4},
Nucleic acid amplification techniques are used for signal generation in antibody-based immunoassays, thereby dramatically enhancing the sensitivity of conventional immunoassays. Methodological aspects, as well as applications of this novel approach, are summarized in this review, with an emphasis on immuno-polymerase chain reaction (IPCR). IPCR is based on chimeric conjugates of specific antibodies and nucleic acid molecules, the latter of which are used as markers to be amplified by PCR for… CONTINUE READING
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