Immuno-Isolating Dual Poly(ethylene glycol) Capsule Prevents Cancer Cells from Spreading Following Mouse Ovarian Tissue Auto-Transplantation

@article{Day2019ImmunoIsolatingDP,
  title={Immuno-Isolating Dual Poly(ethylene glycol) Capsule Prevents Cancer Cells from Spreading Following Mouse Ovarian Tissue Auto-Transplantation},
  author={J. Day and A. David and C. Long and Grace G Bushnell and T. Woodruff and L. Shea and A. Shikanov},
  journal={Regenerative medicine frontiers},
  year={2019},
  volume={2019}
}
For female cancer survivors, premature ovarian insufficiency (POI) is a common complication of anticancer treatments. Ovarian tissue cryopreservation before treatment, followed by auto-transplantation after remission is a promising option to restore fertility and ovarian endocrine function. However, auto-transplantation is associated with the risk of re-introducing malignant cells harbored in the stroma of the ovarian autograft. To mitigate this risk, we investigated in this pilot study whether… Expand
1 Citations
Encapsulated allografts preclude host sensitization and promote ovarian endocrine function in ovariectomized young rhesus monkeys and sensitized mice
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It is demonstrated, for the first time, that encapsulation of ovarian allografteds prevents sensitization and protects the allograft from rejection in young rhesus monkeys and in sensitized mice. Expand

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